Samenvatting

What are the 7 neurotransmitters?
Acetylcholine
serotonin
dopamine
norepinephrine
glutamate
GABA
glycine
Found in:
– motor neurons
Acetylcholine (ACh)
-brain: basal ganglia and nucleus basalis of meynert
-Autonomic nervous system (sympathetic and parasympathetic)
what is acetylcholine used to treat?
1) Alzheimers disease
2) Dementia
acetylcholine receptors nicotinic (excitatory) and muscarinic (excitatory inhibitory)
ionotropic
ligand-gated ion channels
channel opened when ligand activates it
receptors that act through a second messenger system.
indirect enzyme cascade G-protein coupled receptors
metabotropic receptors
Serotonin (5-TH)
found in brained brainstem (pineal gland and raphe nuclei in pons)
involved in limbic function (emotion, mood, hunger, sex, instinct,
temperature, sleep)
what is serotonin 5-TH used to treat depression and sleep regulation
Serotonin receptors
5-HT
-ionotropic 5-HT 3 receptor (excitatory)
-Metabotropic 5-HT 1-7 receptors (excitatory or inhibitory)
Dopamine is found where?
Brain and brainstem
-substantia nigra which is associated with reward, addiction, and
movement
-hypothalamus which inhibits prolactin release
schizophrenia (too much)
parkinsons (too little)
what is dopamine used to treat?
**you need the right balance. If you have Parkinson’s and are
taking dopamine you have to take the right amount or you can
experience psychosis
dopamine receptors
-ionotropic- none
-Metabotropic D1 (excitatory) & D2 (inhibitory)
Norepinephrine is found where?
Brain: locus ceruleus, projecting to cortex and is used for arousal,
attention and anxiety
Autonomic nervous system in the post ganglionic neurons of the
sympathetic neuron

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